Data from the 1970s which appeared to suggest that at the age of 35 years a
woman had a similar chance of delivering a child with aneuploidy as
experiencing a miscarriage after an amniocentesis. That age became "the"
prompt for genetic counseling. Much has been learned since then, and this is
discussed in an article published in the Journal of the American Medical
Association (JAMA) by Berkowitz et al. (Challenging the Strategy of Maternal
Age-Based Prenatal GC, JAMA, 2006; Vol. 295; pp. 1446-1448).