Sorry for the late notification!!!!
Ed
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Endometriosis: Emerging Research and Intervention Strategies
April 9-10, 2001
Lister Hill Center Auditorium
National Institutes of Health
Bethesda, Maryland
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The National Institutes of Health (NIH) scientific workshop "Endometriosis:
Emerging Research and Intervention Strategies," is scheduled for April 9-10,
2001, at the Lister Hill Center Auditorium, located on the campus of the NIH
in Bethesda, Maryland. The workshop will be presented by the National
Institute of Child Health and Human Development and by several of the NIH
Institutes and Offices.
A significant percentage of American women of reproductive age are affected
by endometriosis, which represents a major cause of infertility in women.
The etiology and factors contributing to disease susceptibility remain to be
clarified for the most common disorders of female reproduction, including
endometriosis. The true incidence of endometriosis and its patterns of
initiation, maintenance and progression are not known. While investigators
believe that there may be a genetic basis for susceptibility, the genes
involved are unknown and even their mode of inheritance is debated.
Environmental factors, particularly estrogenic substances, may increase the
risk of endometriosis and other disorders of reproductive tissues. The
biochemical and molecular mechanisms underlying the postulated effects of
these factors, and others such as the immune system, on endometriosis are
poorly understood and are only now being investigated. Understanding the
interaction of these critical elements in the etiology of endometriosis will
have a major impact on women's reproductive health in general as well as
improve fertility via intervention and prevention strategies.
The purpose of the workshop is to formulate a framework for a basic science,
translational, and clinical research agenda on endometriosis. This workshop
will bring together a mutidiciplinary group of clinicians, endocrinologists,
immunologists, reproductive and developmental biology investigators and
other experts in the field to examine issues critical to endometriosis. The
meeting will feature scientific presentations that address the current state
of knowledge, summarize recent findings, identify emerging issues or
continuing gaps in knowledge, and serve as a catalyst for discussion during
the final session on future research directions. This final session and the
panel discussion sessions following the group of presentations will allow
further exploration of research opportunities.
The Program Planning Committee formulated the following objectives of this
workshop:
* To familiarize participants with the state of the science and key
issues related to the basic biology, epidemiology, growth and development,
environmental influences, and genetic expression that characterize
endometriosis;
* To review current intervention strategies and explore the
development of novel therapeutic agents important in optimizing clinical
outcomes; and
* To present potential areas of future research directions and propose
opportunities for research in epidemiology, basic science, and clinical
research.
Session topics include: Overview of Endometriosis; Basic Biology of
Endometriosis; Growth Factors, Cytokines, and Angiogenic Factors; Matrix
Modification in Endometrial Tissue; Immune System and Endometriosis;
Environment and Endometriosis; Genetics and Gene Expression in
Endometriosis; In Vitro and Animal Models of Endometriosis; Intervention
Strategies; and Future Research Directions and Recommendations.
Information regarding the meeting, agenda and registration forms can be
obtained by contacting Audra M. Scott at IQ Solutions, Inc. at (301)
984-1471. You may also reach her by e-mail at [log in to unmask]
ADDITIONAL MEETING INFORMATION
Target Audience: This workshop has been developed for those that are
interested in understanding endometriosis and its impact on the female
reproductive tract and reproductive potential. (1) Practicing physicians
involved in the management and treatment of endometriosis, especially those
in the fields of gynecology and reproductive endocrinology; (2)
Epidemiologists, basic and clinical researchers working on female hormone
biochemistry, physiology, immunology and genetics; and (3) Nurses and other
health care professionals interested in women's reproductive health.
Reasonable Accommodations: For reasonable accommodations, please contact
Audra Scott at (301) 984-1471.
Registration: There is no registration fee for this workshop. Registration
is limited to 175 and pre-registration is encouraged. Registration is on a
first come-first serve basis, so early registration is advised. To register
for the meeting, send the enclosed registration form by fax or e-mail to Ms.
Audra M. Scott. Please indicate your special needs on the enclosed
registration form.
Meeting Venue: The workshop will be held on the campus of the National
Institutes of Health at the Lister Hill Center Auditorium (Building 38A),
8600 Rockville Pike, Building 38A, Bethesda, Maryland 20894.
Hotel Accommodations: A limited block of rooms has been reserved for
attendees at a reduced rate of $119.00 plus tax at hotels close to the NIH.
Please make your reservations directly with one of the following hotels and
reference the "NICHD Endometriosis Meeting" when making your reservations.
Reservations must be made directly with the Holiday Inn or Bethesda Marriott
by March 22, 2001; otherwise, the regular room rate will apply.
Holiday Inn Bethesda
8120 Wisconsin Avenue
Bethesda, MD 20814
Phone: (800) 465-4329 or (301) 652-2000
Bethesda Marriott
5151 Pooks Hill Road
Bethesda, MD 20814
Phone: (800) 228-9290 or (301) 897-9400
Metro Travel: The Lister Hill Center Auditorium is located within walking
distance of the Medical Center stop on the Red Line of the Metrorail subway
system. The NIH also offers shuttle bus service from the Medical Center stop
to the Lister Hill Center (Building 38A) on weekdays. A campus shuttle map
and schedules may be obtained by visiting the web site:
http://des1.od.nih.gov/nihshuttle/shuttle_map_live.asp.
Parking: Please keep in mind that visitor parking on the NIH campus is very
limited. Visitors may park in the attendant-assisted lot across Center Drive
from Lister Hill, beside the Natcher Building. Parking is $2/hour, with a
maximum of $12/day.
Airline Transportation: The NIH campus and hotels are approximately 20 miles
from Reagan National Airport, 24 miles from Dulles International Airport,
and 35 miles from the Baltimore-Washington International Airport.
Ground Transportation: Taxi service is available at all airports. Ground
transportation is also provided by Super Shuttle (phone: 800-258-3826 or
800-BLUEVAN).
Program Planning Committee:
Estella Parrott, M.D., M.P.H., Co-chair
National Institute of Child Health and Human Development
Koji Yoshinaga, Ph.D., Co-chair
National Institute of Child Health and Human Development
Linda C. Giudice, Ph.D., M.D.
Stanford University Medical Center
Jerrold Heindel, Ph.D.
National Institute of Environmental Health Sciences
Kevin G. Osteen, Ph.D.
Vanderbilt University School of Medicine
PRELIMINARY AGENDA
Endometriosis: Emerging Research and Intervention Strategies
April 9-10, 2001
National Institute of Child Health and Human Development
Lister Hill Center Auditorium
National Institutes of Health
Bethesda, Maryland
Agenda
Monday, April 9, 2001
7:00-8:00 Registration
8:00-8:15 Welcome and Opening Remarks
Institute & Office Heads
SESSION I: OVERVIEW (WHAT IS ENDOMETRIOSIS?)
Moderator: Estella Parrott, M.D., M.P.H. (NICHD)
8:15-8:35 Clinical Aspects of Endometriosis
Ana A. Murphy, M.D. (Emory University)
8:35-8:55 Epidemiology of Endometriosis
Daniel W. Cramer, M.D., Sc.D. (Brigham &
Women's
Hospital)
8:55-9:15 The Relationship Between Endometriosis and Infertility
Robert L. Barbieri, M.D. (Harvard Medical
School)
9:15-9:30 Panel Discussion
9:30-9:45 BREAK
SESSION II: BASIC BIOLOGY OF ENDOMETRIOSIS
Moderator: Koji Yoshinaga, Ph.D. (NICHD)
9:45-10:05 Steroid Control of Endometrial Tissue Turnover
Kevin G. Osteen, Ph.D. (Vanderbilt University)
10:05-10:25 Mechanisms of Action of Estrogen and Progesterone
Francesco J. De Mayo, Ph.D. (Baylor College of
Medicine)
10:25-10:45 Premenstrual and Menstrual Cellular Changes in the Primate
Endometrium: Relevance to Endometriosis
Robert M. Brenner, Ph.D. (Oregon Regional
Primate Research Center)
10:45-11:05 Biosynthesis and Action of Estrogen and Progesterone in
Endometriosis
Serdar E. Bulun, M.D. (University of Illinois at
Chicago)
11:05-11:20 Panel Discussion
SESSION III: GROWTH FACTORS, CYTOKINES, AND ANGIOGENIC FACTORS
Moderator: Robert N. Taylor, M.D., Ph.D.
(University of California, San Francisco)
11:20-11:40 Angiogenic Factors in Endometriosis
Robert N. Taylor, M.D., Ph.D. (University of
California, San Francisco)
11:40-12:00 Local Cytokines in Endometrial Tissue
Aydin M. Arici, M.D. (Yale University)
12:00-12:20 Control of Growth and Differentiation of Endometrium
Robert M. Bigsby, Ph.D. (Indiana University)
12:20-12:35 Panel Discussion
12:35-1:35 LUNCH
SESSION IV: MATRIX MODIFICATION IN ENDOMETRIAL TISSUE
Moderator: Kevin G. Osteen, Ph.D.
(Vanderbilt University)
1:35-1:55 Circulating Sex Hormones and Endometrial Matrix
Metalloproteinases
Etienne Marbaix, M.D., Ph.D. (Université
Catholique de Louvain Bruxelles, Belgium)
1:55-2:15 Paracrine Regulation of Matrix Metalloproteinase Expression
in the Normal Human Endometrium
Kevin G. Osteen, Ph.D. (Vanderbilt University)
2:15-2:35 Paracrine Regulation of Matrix Metalloproteinase Expression
in Endometriosis
Kathy L. Sharpe-Timms, Ph.D. (University of
Missouri)
2:35-2:50 Panel Discussion
2:50-3:05 BREAK
SESSION V: IMMUNE SYSTEM AND ENDOMETRIOSIS
Moderator: Phyllis Leppert, M.D., Ph.D.
(NICHD)
3:05-3:25 Immune System in Eutopic and Ectopic Human Endometrium: An
Overview
Joseph A. Hill, M.D. (Harvard Medical School)
3:25-3:45 Regulation and Modulation of Abnormal Immune Responses in
Endometriosis
Neil Sidell, Ph.D. (Emory University)
3:45-4:05 Autoantibody Responses to Carbohydrate Epitopes in
Endometriosis
Grant R. Yeaman, Ph.D. (Dartmouth Medical School)
4:05-4:25 Macrophages, Oxidation, and Endometriosis
Sampath Parthasarathy, Ph.D. (Emory University)
4:25-4:40 Panel Discussion
SESSION VI: ENVIRONMENT AND ENDOMETRIOSIS
Moderator: Jerrold Heindel, Ph.D. (NIEHS)
4:40-5:00 Environmental Effects on Endometriosis: An Overview
John A. McLachlan, Ph.D. (Tulane University)
5:00-5:20 The Potential Role of Environmental Toxins in the
Pathophysiology of Endometriosis
Sherry E. Rier, Ph.D. (Vanderbilt
University)
5:20-5:40 Environmental Contaminants and Dietary Factors in
Endometriosis
Warren G. Foster, Ph.D. (Department of
Health, Government
of Canada)
5:40-6:00 Panel Discussion
6:00 ADJOURN
Tuesday, April 10, 2001
7:00-8:00 Registration
SESSION VII: GENETICS AND GENE EXPRESSION IN ENDOMETRIOSIS
Moderator: Linda C. Giudice, Ph.D., M.D.
(Stanford University)
8:00-8:20 Genetic Epidemiology of Endometriosis in the Rhesus Macaque
Monkey
Steven H. Kennedy, M.D. (Oxford University)
8:20-8:40 Heritability and Molecular Genetic Studies of Endometriosis
Joe Leigh Simpson, M.D. (Baylor College of Medicine)
8:40-9:00 Gene Expression in Endometrium From Women With and Without
Endometriosis
Linda C. Giudice, M.D., Ph.D. (Stanford University)
9:00-9:20 Expression of Genes Relevant to Uterine Receptivity in
Patients With Endometriosis
Bruce A. Lessey, M.D., Ph.D. (University of North
Carolina)
9:20-9:40 Role of Endometriosis in Cancer and Tumor Development
Lillian Swiersz, M.D. (Stanford University)
9:40-10:00 Panel Discussion
10:00-10:15 BREAK
SESSION VIII: IN VITRO AND ANIMAL MODELS OF ENDOMETRIOSIS
Moderator: C. Richard Lyttle, Ph.D.
(Wyeth-Ayerst)
10:15-10:35 An In Vitro Model of Implantation and Invasion of Eutopic
Endometrium
Robert Schenken, M.D. (University of Texas
Health Science
Center at San Antonio)
10:35-10:55 Endometriosis in the Baboon
Asgerally T. Fazleabas, Ph.D. (University of
Illinois at
Chicago)
10:55-11:15 A Rat Model for the Study of Endometriosis
Kathy L. Sharpe-Timms, Ph.D. (University of
Missouri)
11:15-11:35 The Establishment of Human Endometrial Tissues in a Nude
Mouse Model of Endometriosis
Kaylon Bruner-Tran, Ph.D. (Vanderbilt
University)
11:35-11:55 Panel Discussion
11:55-1:00 LUNCH
SESSION IX: INTERVENTION STRATEGIES
Moderator: James Segars, M.D. (NICHD)
1:00-1:20 Conventional Medical Therapies for Endometriosis
Valerie Montgomery-Rice, M.D. (University of Kansas)
1:20-1:40 Surgical Management of Endometriosis
Dan C. Martin, M.D. (Memphis, Tennessee)
1:40-2:00 An Evidence-Based Review of Treatment Strategies
David Olive, M.D. (University of Texas
Southwestern School of Medicine)
2:00-2:20 Novel Therapeutic Concepts
Kristof Chwalisz, M.D., Ph.D. (TAP)
2:20-2:40 Panel Discussion
2:40-3:00 BREAK
SESSION X: FUTURE RESEARCH DIRECTIONS AND RECOMMENDATIONS
Moderators: Koji Yoshinaga, Ph.D. (NICHD),
Estella Parrott, M.D., M.P.H. (NICHD)
3:00-5:00 Jerrold Heindel, Ph.D. (NIEHS), Linda C. Giudice, Ph.D.,
M.D.,
(Stanford University), Kevin G. Osteen,
Ph.D. (Vanderbilt University), Speakers and Participants
5:00 ADJOURN
Meeting Registration Form
National Institute of Child Health and Human Development
NIH Scientific Workshop Endometriosis: Emerging Research and Intervention
Strategies Lister Hill Center Auditorium (Building 38A) National Institutes
of Health Bethesda, Maryland April 9-10, 2001
Please print for legibility:
First Name: Last Name:
(As will appear on badge)
(As will appear on badge)
Title: Degree(s):
Organization:
Address:
City/State/Zip Code:
Telephone: Fax:
E-mail Address:
Special needs (e.g., Sign Language)
*****************************************************
PLEASE FAX THIS FORM OR E-MAIL THIS INFORMATION
BY MARCH 22, 2001 TO:
AUDRA M. SCOTT
IQ SOLUTIONS, INC.
FAX: (301) 984-1473 or E-MAIL: [log in to unmask]
Audrey L. Burwell
National Center for Health Statistics, CDC
6525 Belcrest Road, Room 1100
Hyattsville, MD 20782
Phone: 301.458.4129
Fax: 301.458.4022
Email: [log in to unmask]
Edward E. Rylander, M.D.
D.A.B.F.P and D.A.B.P.M.