Practice parameters for antibiotic prophylaxis to
prevent infective endocarditis or infective prosthesis during colon and rectal
endoscopy.
SOURCE(S):
Dis Colon Rectum 2000 Sep;43(9):1193-200 [61 references]
Practice
Parameters for Antibiotic Prophylaxis
Bacterial
endocarditis is a serious, potentially fatal condition that may be associated
with endoscopic procedures. Antibiotic prophylaxis has been used to prevent
endocarditis, but does involve risks. Endoscopists must assess the evidence and
weigh the risks and benefits. It is the consensus of The Standards Task
Force that antibiotic prophylaxis be considered only for the high-risk groups.
Conditions
Associated with Endocarditis
High risk
·
Prosthetic
cardiac valves
·
History
of endocarditis
·
Surgically
constructed systemic pulmonary shunts
·
Complex
cyanotic congenital heart disease
·
Vascular
grafts (first 6 months after implantation)
Moderate risk
·
Most other cardiac malfunctions
·
Acquired valvular dysfunction
·
Hypertrophic cardiomyalgia
·
Mitral valve prolapse with valvular
regeneration or thickened valves or both
Low risk
·
Vascular graft material (6 months after
implantation)
·
Orthopedic prosthesis
·
Central nervous system ventricular shunts
·
Penile prosthesis
·
Intraocular lens
·
Pacemakers
·
Local tissue augmentation material
·
Isolated secundum atrial septal defect
·
Previous coronary bypass
·
Mitral valve prolapse without valvular
degeneration
·
Physiologic heart murmurs
·
Previous rheumatic fever without valvular
dysfunction
·
Cardiac pacemaker
It is the consensus of The Standards Task Force that
antibiotic prophylaxis be considered only for the high-risk groups.
Nonvalvular
and Noncardiac Prosthesis
Prophylactic
Regimens
It is impossible to
make recommendations for all clinical situations. Practitioners must choose the
anti-biotic and determine the dosage based on the special circumstances of each
case. Adult prophylactic regimens listed in the table below are representative
of recommendations made by the American Heart Association (AHA). Although the
other organisms may be cultured after lower endoscopy, enterococcus is the most
likely cause of endocarditis; therefore, the prophylactic regimens are directed
primarily against enterococci.
Adult
Prophylactic Regimens:
Drug |
Adult Dosage Regimen |
Ampicillin, gentamicin, and amoxicillin |
Intravenous or intramuscular administration of ampicillin
(2.0 g) plus gentamicin (1.5 mg/kg; not to exceed 120 mg) 30 minutes before
procedure, followed by amoxicillin (1 g) orally 6 hours after initial dose or
ampicillin 1 g intramuscularly or intravenously. |
Vancomycin and gentamicin* |
Intravenous administration of vancomycin (1.0 g) over 1 to
2 hours plus intravenous or intramuscular administration of gentamicin (1.5
mg/kg; not to exceed 120 mg), complete infusion within 30 minutes of starting
procedure. |
Amoxicillin** or ampicillin |
Amoxicillin 2 g orally or ampicillin 2 g intramuscularly
or intravenously within 30 minutes of starting procedure. |
*Ampicillin or
amoxicillin or penicillin-allergic regimen.
**Alternative
moderate-risk regimen.
CLINICAL
ALGORITHM(S):
None provided
DEVELOPER(S):
American Society of Colon and Rectal Surgery (ASCRS) - Medical Specialty
Society
COMMITTEE:
Standards Task Force, American Society of Colon and Rectal Surgeons
GROUP
COMPOSITION:
Task Force Members: Greg Oliver, M.D., Project Director, Ann
Lowry, M.D., Committee Chair, Anthony Vernava, M.D., Vice Chairman, Terry
Hicks, M.D., Council Representative, Marcus Burnstein, M.D., Frederick
Denstman, M.D., Victor Fazio, M.D., Bruce Kerner, M.D., Richard Moore, M.D.,
Walter Peters, M.D., Theodore Ross, M.D., Peter Senatore, M.D., Clifford
Simmang, M.D., Steven Wexner, M.D., W. Douglas Wong, M.D.
ENDORSER(S):
Not stated
GUIDELINE
STATUS:
This is the current release of the guideline. This guideline updates a
previously issued guideline (Practice parameters for antibiotic prophylaxis to
prevent infective endocarditis or infected prosthesis during colon and rectal
endoscopy. The American Society of Colon and Rectal Surgeons. Dis Colon Rectum
1992 Mar;35[3]:277).
GUIDELINE
AVAILABILITY:
Electronic copies: Available from the American
Society of Colon and Rectal Surgeons (ASCRS) Web site.
Print copies:
Available from ASCRS, 85 W. Algonquin Road, Suite 550, Arlington Heights,
Illinois 60005.
COMPANION
DOCUMENTS:
The following is available:
·
Oliver G, Lowry A, Vernava A, Hicks T,
Burnstein M, Denstman F, Fazio V, Kerner B, Moore R, Peters W, Ross T, Senatore
P, Simmang C, Wexner S, Wong Practice parameters for antibiotic
prophylaxis--supporting documentation. The Standards Task Force. The American
Society of Colon and Rectal Surgeons. Dis Colon Rectum. 2000
Sep;43(9):1194-200.
Electronic copies:
Available from the American
Society of Colon and Rectal Surgeons (ASCRS) Web site.
Print copies:
Available from ASCRS, 85 W. Algonquin Road, Suite 550, Arlington Heights,
Illinois 60005.
Edward E.
Rylander, M.D.
Diplomat American
Board of Family Practice.
Diplomat American
Board of Palliative Medicine.